Skip to Content
Merck
All Photos(3)

Documents

ABN131

Sigma-Aldrich

Anti-GABA Antibody

from rabbit, purified by affinity chromatography

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

species reactivity (predicted by homology)

all

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

General description

Neurotransmitters can be defined as chemical substances that are released by the presynaptic neuron before being bound by receptors on the postsynaptic cell surface. It has been well established that the nervous system utilizes neurotransmitters for cell signaling. Neurotransmitters can be divided into two groups; low molecular weight transmitter molecules such as biogenic amines, purines, or amino acids, and bioactive peptides, of which more than 50 members have been identified in the mammalian central nervous system. Many low molecular weight neurotransmitters are produced within the axon terminal from common cellular metabolites and packaged into synaptic vesicles. The transport and delivery of vesicles containing neurotransmitter is a highly regulated and complex process. GABA (g-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system that is involved in the pathogenesis of certain neurological and psychiatric disorders. GABA is produced from glutamic acid in a reaction catalyzed by glutamic acid decarboxylase. GABA interacts with the GABAA and GABAB receptors, which are widely distributed throughout the nervous system and in a variety of cell types. The immunolocalization, neuronal distribution, and vesicular compartmentalization of neurotransmitter molecules and their precursors are important for understanding the modulation, regulation, and function of neurotransmitters in the nervous system.

Application

Anti-GABA Antibody is a highly specific rabbit polyclonal antibody, that targets GABA & has been tested in IHC (Paraffin) & Enzyme Immunoassay (ELISA).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABA in rat brain tissue (Note: Non-specific staining may be observed in vascular tissues.).

ELISA Analysis: A representative lot from an independent laboratory detected GABA in a competitive ELISA.

Quality

Evaluated by Immunohistochemistry (Paraffin) in Rat brain tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected GABA in Rat brain tissue sections.

Linkage

Replaces: AB131

Analysis Note

Control
Rat hypothalamus tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Christopher Murphy Lewis et al.
Cell reports, 35(5), 109083-109083 (2021-05-06)
Synchronization has been implicated in neuronal communication, but causal evidence remains indirect. We use optogenetics to generate depolarizing currents in pyramidal neurons of the cat visual cortex, emulating excitatory synaptic inputs under precise temporal control, while measuring spike output. The
Takamasa Mizoguchi et al.
Development (Cambridge, England), 147(16) (2020-08-29)
In the vertebrate ventral spinal cord, p2 progenitors give rise to two interneuron subtypes: excitatory V2a interneurons and inhibitory V2b interneurons. In the differentiation of V2a and V2b cells, Notch signaling promotes V2b fate at the expense of V2a fate.
Melissa M Martin et al.
Cerebral cortex (New York, N.Y. : 1991), 30(3), 1830-1842 (2019-10-11)
Cigarette smoking during pregnancy is a major public health concern, resulting in detrimental health effects in the mother and her offspring. The adverse behavioral consequences for children include increased risk for attention deficit hyperactivity disorder, working memory deficits, epilepsy, novelty-seeking
Rebecca A Senft et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(12), 2581-2600 (2021-02-07)
Brainstem median raphe (MR) neurons expressing the serotonergic regulator gene Pet1 send collateralized projections to forebrain regions to modulate affective, memory-related, and circadian behaviors. Some Pet1 neurons express a surprisingly incomplete battery of serotonin pathway genes, with somata lacking transcripts
Tuyana Malankhanova et al.
Journal of personalized medicine, 10(4) (2020-11-14)
Huntington's disease (HD) is a severe neurodegenerative disorder caused by a CAG triplet expansion in the first exon of the HTT gene. Here we report the introduction of an HD mutation into the genome of healthy human embryonic fibroblasts through

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service