SRP4136
IL-3 from rat
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
HCGF, IL-3, Interleukin-3, MCGF (Mast cell growth factor), MGC79398, Multi-CSF, P-cell stimulation factor
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About This Item
biological source
rat
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
<10 ng/mL ED50
mol wt
~15.8kDa
packaging
pkg of 10 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Il3(24495)
General description
Interleukin-3 (IL-3) is a species-specific colony-stimulating factor that stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Recombinant rat IL-3 is a 15.8 kDa protein.
Physical form
Sterile filtered and lyophilized from 5 mM sodium citrate, pH 4.0.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 μg/μL. The solution can be diluted into other aqueous buffers.
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Weidong Yu et al.
Carcinogenesis, 29(9), 1717-1724 (2008-05-06)
Abl interactor (Abi) 1 was first identified as the downstream target of Abl tyrosine kinases and was found to be dysregulated in leukemic cells expressing oncogenic Bcr-Abl and v-Abl. Although the accumulating evidence supports a role of Abi1 in actin
Kerstin Kapp et al.
Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist
Orit Uziel et al.
Biochemical and biophysical research communications, 450(1), 274-282 (2014-06-08)
Treatment with erythropoietin (EPO) in several cancers is associated with decreased survival due to cancer progression. Due to the major importance of telomerase in cancer biology we hypothesized that some of these effects may be mediated through EPO effect on
Cristina Ghirelli et al.
Cancer research, 75(14), 2775-2787 (2015-05-16)
Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid predendritic cells (pDC), a cell type critical to anti-viral immunity.
Jun Ho Lee et al.
Toxicology and applied pharmacology, 285(3), 179-186 (2015-04-23)
Mast cells, constituents of virtually all organs and tissues, are critical cells in IgE-mediated allergic responses. The aim of this study was to investigate the effect and mechanism of an indoxyl chromogenic compound, 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, on IgE-mediated mast cell
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