The EMCN (endomucin) gene is mapped to human chromosome 4q24. It encodes a 80−120kDa transmembrane sialomucin. Mucin-14 is predominantly expressed in heart, kidney and lungs. Endomucin is a surface glycoprotein localized to the endothelial cells. Mucin-14 is a type 1 integral protein. Endomucin possesses 261 amino acid residues and a serine/threonine-rich extracellular domain. Anti-Mucin-14 Antibody detects endogenous levels of total Mucin-14 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Mucin-14.
Immunogen Range: 201-250
Biochem/physiol Actions
Mucin-14 controls lymphocyte adhesion and its expression is associated with the pathogenesis of rheumatoid arthritis. Mucin-14 associated with O-glycans enables it to promote cell−matrix and cell-cell interactions.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of rheumatology, 38(2), 221-228 (2010-12-17)
Endomucin, an endothelial-specific sialomucin, is thought to facilitate "lymphocyte homing" to synovial tissues, resulting in the major histopathologies of rheumatoid arthritis (RA). We examined the association between RA susceptibility and the gene coding endomucin, EMCN. Association studies were conducted with
Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on quiescent endothelial cells enables neutrophils to adhere firmly, via LFA-1-mediated binding
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