Calmodulin 3 (CALM3) encodes calmodulin (CaM) protein 3 which is expressed five folds more than CALM1 and CALM2. CALM3 promoter has high GC content and no TATA box like that of housekeeping gene. CALM3 contains several pro-alpha1 (AP1) and pro-alpha2 (AP2) consensus sites and several CAAT regions. CALM3 also has clusters of specificity protein 1 (SP1) transcription factor. In human chromosome, the gene is localized on 19q13.32.
Specificity
The antibody detects endogenous level of Calmodulin only when phosphorylated at threonine 79/serine 81.
Immunogen
Peptide sequence around phosphorylation site of threonine79/serine81(K-D-T(p)-D-S(p)-E-E) derived from Human Calmodulin .
Biochem/physiol Actions
Calmodulin (CaM) encoded by Calmodulin 3 (CALM3) senses Ca2+ and binds to free signal-transducing protein that regulates Cav1.2 L-type calcium channel and deactivates Cav1.2 when CaM binds to free Ca2+. A sporadic mutation in CALM3 might be the cause for long QT syndrome, a disorder of ventricular myocardial repolarization, characterized by prolonged heart rate. CALM3 expression is higher in teratoma cells. CALM3 is a potential biomarker to dysregulate the melanoma cancer genes. Polymorphism in CALM3 is a potential modifier gene for familial hypertrophic cardiomyopathy.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALMS
Toutenhoofd SL, et al.
Cell Calcium, 23(5), 323-338 (1998)
Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer
Goto Y, et al.
Febs Letters, 588(10), 1973-1982 (2014)
Identification of melanoma biomarkers based on network modules by integrating the human signalling network with microarrays
Huang C, et al.
Journal of Cancer Research and Therapeutics, 10(7), 114-124 (2014)
A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy
Friedrich FW, et al.
European Heart Journal, 30(13), 1648-1655 (2009)
CALM3 mutation associated with long QT syndrome
Reed GJ, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 12(2), 419-422 (2015)
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