SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5′ untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5′ UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.
Immunogen
SNURF (NP_005669, 9-42) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human SNURF.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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