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O9505

Sigma-Aldrich

Orotidine

≥90% (HPLC)

Synonym(s):

Uridine-6-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O8
CAS Number:
314-50-1
Molecular Weight:
288.21
MDL number:
MFCD00057418
UNSPSC Code:
41106305
PubChem Substance ID:
329818941
Pricing and availability is not currently available.

Assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C(=O)NC(=O)C=C2C(O)=O

InChI

1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1

InChI key

FKCRAVPPBFWEJD-XVFCMESISA-N

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Application

Orotidine, a nucleoside found naturally in fungi, bacteria and plants, may be used as a reference for the determination of presence of orotidine in urine or plasma due to urea cycle-related (transamidation) metabolic deficiencies or diseases.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048H5860
041K7017
115H7819
091H7860
076H7857

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H Nagasaka et al.
The Journal of pediatrics, 138(3), 432-434 (2001-03-10)
A liver transplantation from an asymptomatic mother, who was a carrier of ornithine transcarbamylase deficiency, to her daughter, who had severe manifestation, was successfully performed. One-year monitoring of plasma amino acid and urinary orotate/orotidine levels revealed no abnormality in the
D Daniewska-Michalska et al.
Nephron, 64(2), 193-197 (1993-01-01)
The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis
J A Arranz et al.
Clinical chemistry, 45(7), 995-1001 (1999-07-01)
The diagnosis of heterozygosity for X-linked ornithine carbamoyltransferase (OCT) deficiency has usually been based on measurement of the increase of orotate and orotidine excretion after an allopurinol load. We examined the choices of analyte, cutoff, and test conditions to obtain
I Sebesta et al.
Clinica chimica acta; international journal of clinical chemistry, 224(1), 45-54 (1994-01-14)
The increase in orotidine excretion following a 300 mg allopurinol dose has been used for carrier detection in ornithine carbamoyl transferase (OCT) deficiency. This test was evaluated, using three collection periods, in 23 healthy women, 4 obligate heterozygotes and 32
M A Carducci et al.
In vivo (Athens, Greece), 12(3), 271-274 (1998-08-26)
Allopurinol induced pyrimidinuria is a sensitive and specific test that identifies the increased de novo pyrimidine mononucleotide biosynthesis accompanying ornithine trans carbamylase deficiency. We hypothesize that the increased de novo DNA synthesis characteristic of malignant tumors can be detected using
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