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L5756

Sigma-Aldrich

Lithocholic acid 3-sulfate disodium salt hydrate

Synonym(s):

3α-Hydroxy-5β-cholan-24-oic acid 3-sulfate, Sulfolithocholic acid

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About This Item

Empirical Formula (Hill Notation):
C24H38Na2O6S · xH2O
CAS Number:
64936-81-8
Molecular Weight:
500.60 (anhydrous basis)
MDL number:
MFCD06200259
UNSPSC Code:
12161900
PubChem Substance ID:
24896416
Pricing and availability is not currently available.

Assay

≥95% (TLC)

storage temp.

−20°C

SMILES string

[Na+].[Na+].[H]O[H].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](C2)OS([O-])(=O)=O

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048H5005
105K5001
054K5016
100H7803

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Serum-sulfated lithocholate as an indicator of cholestasis during parenteral nutrition in infants and children.
M K Farrell et al.
JPEN. Journal of parenteral and enteral nutrition, 6(1), 30-33 (1982-01-01)
H Takikawa et al.
Biochimica et biophysica acta, 1004(2), 147-150 (1989-08-08)
Biliary excretion and biotransformation of tracer doses of [14C]lithocholic acid and its sulfate and glucuronide intravenously injected into bile-drainaged rats were compared. Biliary excretion efficiency was in the order of unconjugate sulfate glucuronide and all conjugates were completely excreted into
H Takikawa et al.
Journal of hepatology, 22(1), 88-93 (1995-01-01)
It has been suggested that vesicular transport of bile acids in hepatocytes occurs, especially at high-dose loads. The effect was studied of colchicine, a vesicular transport inhibitor, on lithocholate-3-O-glucuronide-induced cholestasis in rats. Cholestasis was induced by an intravenous infusion of
Lithocholate sulphation in the baboon.
M J Dew et al.
Journal of medical primatology, 11(1), 59-64 (1982-01-01)
J M Little et al.
Hepatology (Baltimore, Md.), 14(4 Pt 1), 690-695 (1991-10-01)
The 3-O-glucuronide of lithocholic acid has been shown to be a potent cholestatic agent in rats. However, even after the onset of lithocholic acid glucuronide-induced cholestasis, little of the administered material was recovered in urine. To determine whether this phenomenon
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