The purity of this product is determined by HPLC. While the item is not listed specifically as suitable for HPLC, the material is expected to perform well in this application.
I4125
Inosine
≥99% (HPLC)
Synonym(s):
(−)-Inosine, Hypoxanthine 9-β-D-ribofuranoside
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All Photos(6)
About This Item
Empirical Formula (Hill Notation):
C10H12N4O5
CAS Number:
Molecular Weight:
268.23
Beilstein:
624896
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Pricing and availability is not currently available.
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Quality Level
Assay
≥99% (HPLC)
mp
222-226 °C (dec.) (lit.)
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3C(=O)NC=Nc23
InChI
1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1
InChI key
UGQMRVRMYYASKQ-KQYNXXCUSA-N
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General description
Inosine is a non-canonical nucleotide majorly present as monophosphate. It has ability to base pair with deoxythymidine, deoxyadenosine and deoxyguanosine.[1] Incorporation of inosine in place of guanine modulates translational events.[2] Inosine has antioxidant, anti-inflammatory and neuroprotective functionality. Inosine is prescribed as a therapeutic supplement for nerve injury, inflammation and oxidative stress.[3] It modulates biological processes through adenosine receptors. Its enhances neurite outgrowth in depressive disorders via adenosine receptors.[4] Inosine is also used for treating sepsis in infections.[5]
Application
Biochem/physiol Actions
Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Inosine in DNA and RNA
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Current Opinion in Genetics & Development, 26, 116-123 (2014)
Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture
Liaudet L, et al.
American Journal of Respiratory and Critical Care Medicine, 164(7), 1213-1220 (2001)
Inosine induces context-dependent recoding and translational stalling
Licht K, et al.
Nucleic Acids Research (2018)
Oral administration of inosine produces antidepressant-like effects in mice
Muto J, et al.
Scientific Reports, 4, 4199-4199 (2014)
Inosine-a Multifunctional Treatment for Complications of Neurologic Injury
Doyle C, et al.
Cellular Physiology and Biochemistry, 49(6), 2293-2303 (2018)
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