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E5264

Supelco

2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate

analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):
C20H23N · HClO4
CAS Number:
66729-78-0
Molecular Weight:
377.86
MDL number:
MFCD00132956
UNSPSC Code:
41116107
PubChem Substance ID:
329799066

grade

analytical standard, for drug analysis

Quality Level

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

OCl(=O)(=O)=O.C\C=C1/N(C)C(C)CC1(c2ccccc2)c3ccccc3

InChI

1S/C20H23N.ClHO4/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;2-1(3,4)5/h4-14,16H,15H2,1-3H3;(H,2,3,4,5)/b19-4-;

InChI key

CBNJWAYHGKHAFJ-YOJQKEKBSA-N

General description

2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate is a primary metabolite of methadone.[1]

Application

2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate has been used as a standard in the quantitative determination of of methadone and metabolites in human meconium using liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry technique (LC–APCI–MS/MS).[1]
A metabolite of methadone, useful as a marker in GC-MS analyses.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000267441
0000235745
0000267441
0000235745
128M4099V

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Determination of methadone, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine, 2-ethyl-5-methyl-3, 3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry
Choo.ER, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 814, 369-373 (2005)
G I Kang et al.
Journal of chromatography, 231(2), 311-319 (1982-09-10)
The analysis of methadone and its metabolites in biological fluids by gas chromatography--mass spectrometry is described with deuterated methadone and metabolites as internal standards. The method allowed the determination of 20 ng methadone in 0.5 ml of plasma or saliva.
Karen Marie Dollerup Holm et al.
Journal of analytical toxicology, 36(7), 487-496 (2012-07-11)
We developed a method based on liquid chromatography coupled with tandem mass spectrometry to quantify individual enantiomers of methadone and its primary metabolite, R/S-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), in postmortem blood and brain tissue. Samples were prepared with a Tecan Evo robotic system.
Maksymilian Kulza et al.
Przeglad lekarski, 67(10), 925-928 (2010-01-01)
Methadone maintenance therapy is one of the most popular treatments for opiate addiction. The easiest and the most reliable way to monitor the accuracy of the therapy is determination of methadone and its metabolites in biological material. The aim of
Cristiana Gambelunghe et al.
Annals of clinical and laboratory science, 43(1), 22-30 (2013-03-07)
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment
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