Unfortunately, the specific isoforms that this antibody reacts to have not been investigated. The immunogen is from the C-terminus. Please see the links below to review additional information that may be helpful:
NP_851996
https://www.ncbi.nlm.nih.gov/protein/NP_851996
Entrez Gene 4684 Human
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=4684
Product 156R-9 is not currently sold in your country. Contact Technical Service
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biological source
rabbit
Quality Level
100
500
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
MRQ-42, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (156R-94)
vial of 0.5 mL concentrate (156R-95)
bottle of 1.0 mL predilute (156R-97)
vial of 1.0 mL concentrate (156R-96)
bottle of 7.0 mL predilute (156R-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1
control
neuroblastoma
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
Gene Information
human ... NCAM1(4684)
General description
CD56, also known as a neural cell adhesion molecule (NCAM), is a calcium-independenthomophilic binding protein that belongs to a group of cell adhesion molecules includingcadherins, selectins, and integrins. CD56 is involved in cell-cell adhesion of neural cellsduring embryogenesis and is expressed in most neuroectodermally derived tissues. Innormal tissue, anti-CD56 labels neurons, glia, Schwann cells, NK (natural killer) cells, and asubset of T-cells. CD56 expression can be seen in most NK cell neoplasms,4 and is frequentlyused to identify neoplasms with neuroendocrine differentiation.
Quality
 IVD |  IVD |  IVD |  RUO |
Linkage
CD56 Positive Control Slides, Product No. 156S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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R Michalides et al.
International journal of cancer. Supplement = Journal international du cancer. Supplement, 8, 34-37 (1994-01-01)
The presence of the neural cell adhesion molecule, NCAM, is indicative for a poor prognosis in lung-cancer patients. Using MAb 735, we have investigated the expression of polysialic acid, PSA, on NCAM in a spectrum of neuro-endocrine lung tumors, ranging
Jianguo Tao et al.
The American journal of surgical pathology, 26(1), 111-118 (2002-01-05)
We report an unusual case of aggressive natural killer (NK)-like cytotoxic T-cell lymphoma in a previously healthy immunocompetent West African male. He presented with a fever of unknown origin, subsequently developed erythematous skin nodules, generalized lymphadenopathy, and hepatosplenomegaly, and then
Scott A Ely et al.
The American journal of pathology, 160(4), 1293-1299 (2002-04-12)
Unlike monoclonal gammopathy of undetermined significance (MGUS) or non-Hodgkin's lymphomas (NHLs) with plasmacytoid differentiation, multiple myeloma (MM) is commonly associated with lytic bone lesions. Although the mechanisms of increased osteoclast activity are partially understood, comparatively little is known about the
O Kaufmann et al.
Human pathology, 28(12), 1373-1378 (1998-01-07)
CD56 is immunohistochemically detectable in virtually all small cell carcinomas on frozen sections. The authors retrospectively tested the usefulness of the monoclonal antibody 123C3 against CD56 to differentiate pulmonary and extrapulmonary small cell carcinomas from nonneuroendocrine non-small cell carcinomas by
R E Kibbelaar et al.
European journal of cancer (Oxford, England : 1990), 27(4), 431-435 (1991-01-01)
We investigated the expression of the neural cell adhesion molecule (NCAM) in a series of surgically resected lung carcinomas of various histological subtypes by means of a panel of monoclonal antibodies recognising different N-CAM epitopes. In a subgroup of 56
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Which isoforms of the CD56 antigen does the CD56 MRQ-42 clone recognize? I am curious about the 120kD, 140kD, and 180 kD isoforms, in particular.
1 answer-
Helpful?
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What is the stability of cut slides for staining with the CD56 MRQ-42 clone, particularly for slides that have been sectioned 6 months to 1 year ago and stored at -20°C with desiccant?
1 answer-
It is generally recommended to begin with fresh cut tissue for use in IHC. When storing pre-cut tissue slides, it is typically done under refrigerated conditions (2 to 8°C), which can last for 2 to 3 years. However, the potential effects of storing at temperatures of -20°C with desiccant are not well-known in terms of tissue preservation. The best practice is to always use fresh cut tissue sections when possible.
Helpful?
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Is there information on what terminus was for CD56 MRQ-42?
1 answer-
Based on the information available, it seems that it is C-terminus.
Helpful?
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