Journal of chromatography, 308, 143-151 (1984-06-08)
A new sensitive and selective capillary column gas chromatographic method for the anti-cholinergic agent glycopyrronium bromide in human plasma is described. The procedure involves preliminary ion-pair extraction of the drug into dichloromethane, followed by concentration and analysis of the ion-pair
Research communications in chemical pathology and pharmacology, 36(3), 503-506 (1982-06-01)
The mydriatic effects of mepenzolate, a quarternary antimuscarinic agent, has been investigated and compared with those of atropine by pupillographic analysis in rabbits. The time-response curve for the onset of action for the agents (half-time, ca.5 min) was the same
Journal of ethnopharmacology, 45(3), 215-222 (1995-03-01)
In our attempt to isolate the pharmacologically active ingredients in the aqueous extracts of Mareya micrantha, we have selected the contractions of the longitudinal muscle of the isolated guinea-pig ileum preparation as a pharmacological marker to monitor retention of pharmacological
Journal of cardiovascular pharmacology, 6(6), 1148-1155 (1984-11-01)
The possible interaction between the muscarinic receptor and the antiarrythmic drug amiodarone was studied physiologically in the guinea pig ileum, as well as by competition binding experiments in rat brain and cardiac tissues, using the highly specific tritiated muscarinic antagonist
To investigate the function of the muscarinic cholinergic receptor (mAchR) in narcolepsy and the effects of pharmacotherapy on mAchRs. Muscarinic neural transmission serves as the main executive system in REM sleep. Studies in canine narcolepsy reported an increase in mAchRs
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