These products are for research use only and have not been evaluated for in vivo applications. To assess potential differences between this product and M3262, it is recommended to consult the Certificates of Analysis: https://www.sigmaaldrich.com/product/mm/454575#product-documentation and https://www.sigmaaldrich.com/product/sigma/m3262#product-documentation
454575
N-Methyl-D-aspartic Acid hydrate
>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem®
Synonym(s):
N-Methyl-D-aspartic Acid, Hydrate, NMDA
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100 MG
€143.00
About This Item
Empirical Formula (Hill Notation):
C5H9NO4 · xH2O
CAS Number:
Molecular Weight:
147.13 (anhydrous basis)
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.77
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Product Name
N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
Quality Level
description
Merck USA index - 14, 6662
Assay
>95% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
N([C@H](CC(=O)O)C(=O)[O-])C
InChI
1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
InChI key
HOKKHZGPKSLGJE-GSVOUGTGSA-M
General description
An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca2+ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Glutamate receptor that regulates Ca2+ channels
Glutamate receptor that regulates Ca2+ channels
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.
Other Notes
Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Xinzheng Guo et al.
STAR protocols, 2(4), 100932-100932 (2021-11-23)
The degeneration of retinal ganglion cells (RGCs) leads to irreversible vision loss in a variety of pathological states. Here, we describe a protocol to evaluate the role of a gene in protecting mouse RGCs when they sustain injuries from excitotoxicity
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What's the difference between CAS Number: 6384-92-5 and CAS Number:454575? (They are both NMDA). Which are applicable to be used in a NMDA lesion surgery?
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