OK to freeze desiccated (hygroscopic) protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.
Biochem/physiol Actions
Cell permeable: yes
Primary Target caspase-8
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Irritant (B)
Sequence
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
Physical form
A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
≥98% (HPLC)
Other Notes
Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345. Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - (refers to pure substance)
Flash Point(C)
87 °C - (refers to pure substance)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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