850371C

22:0 PC

1,2-dibehenoyl-sn-glycero-3-phosphocholine, chloroform

• Synonym(s): 1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)
• Empirical Formula (Hill Notation): C₅₂H₁₀₄NO₈P
• CAS Number: 37070-48-7
• Molecular Weight: 902.36
• MDL number: MFCD00063529
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 2.5 mL (850371C-25mg); pkg of 1 × 20 mL (850371C-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 850371C
• concentration: 10 mg/mL (850371C-25mg); 25 mg/mL (850371C-500mg)
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [P](=O)([O-])(OCC[N+](C)(C)C)OCC(OC(=O)CCCCCCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCCCCCC
• InChI: 1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3
• InChI key: HRTBOPUWPUXROO-UHFFFAOYSA-N

Description

General description

Phosphatidylcholines are phospholipids, that are abundantly present in the membrane. They have fatty acids in the sn-1 and sn-2 positions, that are covalently attached to a glycerol with the help of ester bonds.[1]

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

22:0 PC may be used:

• to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity[2]
• to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)[3]
• as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC) [4]

Biochem/physiol Actions

The physical properties of membranes can be modulated with the help of fatty acyl configuration of phosphatidylcholines. They act as a vital source for eicosanoids.[1]

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850371C-500mg)

5 mL Clear Glass Sealed Ampule (850371C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Target Organs: Liver,Kidney, Respiratory system
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash