810211P

C12-NBD Ceramide

Avanti Research^™ - A Croda Brand 810211P, powder

• Synonym(s): N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine
• Empirical Formula (Hill Notation): C₃₆H₆₁N₅O₆
• CAS Number: 202850-01-9
• Molecular Weight: 659.90
• MDL number: MFCD02259239
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (810211P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 810211P
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO
• InChI: 1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1
• InChI key: SNOJCYCOPNIGIK-ULETYAGTSA-N

Description

General description

C12 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) ceramide is a long-chain fluorescent phospholipid.[1] It is a natural analog of ceramide with C12 acyl chain length.[2]

Application

C12-NBD Ceramide or N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine has been used as a substrate in ceramidase activity assay.[3] It is also suitable for the lipid binding assays[4] and in cell culture experiments for endothelial cells to determine the pro-apoptotic intracellular ceramide generation.[5]

Biochem/physiol Actions

C12-7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) Ceramide is useful for measuring the alkaline and neutral ceramidase activity.[1] It is involved in maintainingthe physical properties of ceramide required for cellular studies.[2]

Packaging

5 mL Amber Glass Screw Cap Vial (810211P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids