Neurodegeneration is linked to protein aggregation in several human disorders. In Huntington's disease, the length of a polyglutamine stretch in Huntingtin is correlated to neuronal death. Here we utilize a model based on glutamine stretches of 0, 30 or 56
Biochimica et biophysica acta, 1827(3), 446-454 (2013-01-15)
Membrane-bound respiratory complex I in inside-out submitochondrial particles (SMP) catalyzes both superoxide and hydrogen peroxide formation in NADH- and/or succinate-supported reactions. At optimal NADH concentration (50μM), the complex I-mediated process results in a formation of two superoxide anions and H(2)O(2)
Biochemistry and cell biology = Biochimie et biologie cellulaire, 91(2), 72-78 (2013-03-27)
Very few studies have been done to understand the effect of millimolar concentrations of chaotropes on protein structure. In our previous study we observed that the secondary and tertiary structure of human serum albumin (HSA) increases in the presence of
Reaction of cis-[Cl(2)Pt(S(O)Me(2))(2)] with 1 equiv of sym-N,N',N″-triarylguanidines, ArN═C(NHAr)(2) (sym = symmetrical; Ar = 2-MeC(6)H(4) (LH(2)(2-tolyl)), 2-(MeO)C(6)H(4) (LH(2)(2-anisyl)), 4-MeC(6)H(4) (LH(2)(4-tolyl)), 2,5-Me(2)C(6)H(3) (LH(2)(2,5-xylyl)), and 2,6-Me(2)C(6)H(3) (LH(2)(2,6-xylyl))) in toluene under reflux condition for 3 h afforded cis- or trans-[Cl(2)Pt(S(O)Me(2))(ArN═C(NHAr)(2))] (Ar = 2-MeC(6)H(4)
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