血小板衍生生长因子是在哺乳动物血清中发现的主要促分裂原，在凝血过程中从血小板释放。1PDGF与多种细胞发生多功能作用，包括中胚层来源细胞的有丝分裂、细胞外基质合成增加以及中性粒细胞、单核细胞和成纤维细胞的趋化和活化。PDGF 对真皮和肌腱成纤维细胞、血管平滑肌细胞、神经胶质细胞和软骨细胞有促有丝分裂作用。PDGF似乎在促进伤口愈合中可与转化生长因子-1相互作用。2 然而，PDGF也可能在动脉硬化和肿瘤形成中具有致病性。3 所有PDGF产物的促有丝分裂活性都通过Swiss 3T3细胞或NR6-3T3成纤维细胞在培养物中进行了检测。4
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参考文献
1.
Ross R, Glomset J, Kariya B, Harker L. 1974. A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro. Proceedings of the National Academy of Sciences. 71(4):1207-1210. https://doi.org/10.1073/pnas.71.4.1207
2.
Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Griffin GL, Senior RM, Deuel TF. 1989. Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms.. 109(1):429-440. https://doi.org/10.1083/jcb.109.1.429
3.
Ross R. 1981. George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.. Arteriosclerosis. 1(5):293-311. https://doi.org/10.1161/01.atv.1.5.293
4.
Raines EW, Ross R. 1985. [58] Purification of human platelet-derived growth factor.749-773. https://doi.org/10.1016/0076-6879(85)09128-5
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