跳转至内容

Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation.

Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation.

Journal of neuroimmunology (2015-03-17)

Chao Zhen, Xuedan Feng, Zhe Li, Yabo Wang, Bin Li, Lin Li, Moyuan Quan, Gaoning Wang, Li Guo

摘要

Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)2D3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms. EAE was induced in C57BL/6 mice via immunization with MOG35-55, and some mice received 1,25(OH)2D3. 1,25(OH)2D3 inhibited EAE progression. Additionally, 1,25(OH)2D3 reduced inflammation, demyelination, and neuron loss in the spinal cord. The protective effect of 1,25(OH)2D3 was associated with significantly elevated expression of Beclin1, increased Bcl-2/Bax ratio, and decreased LC3-II accumulation. Thus, 1,25(OH)2D3 may represent a promising new MS treatment.

材料

货号

品牌

产品描述

Sigma-Aldrich

十二烷基硫酸钠, BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC)

Sigma-Aldrich

蔗糖, for molecular biology, ≥99.5% (GC)

Sigma-Aldrich

蔗糖, ≥99.5% (GC)

Sigma-Aldrich

十二烷基硫酸钠, ≥99.0% (GC), dust-free pellets

Sigma-Aldrich

蔗糖, ≥99.5% (GC), BioXtra

Sigma-Aldrich

蔗糖, BioUltra, for molecular biology, ≥99.5% (HPLC)

Sigma-Aldrich

十二烷基硫酸钠溶液, BioUltra, for molecular biology, 10% in H₂O

USP

蔗糖, United States Pharmacopeia (USP) Reference Standard

Sigma-Aldrich

十二烷基硫酸钠溶液, BioUltra, for molecular biology, 20% in H₂O

Sigma-Aldrich

十二烷基硫酸钠, BioUltra, for molecular biology, ≥99.0% (GC)

Sigma-Aldrich

1α,25-二羟基维生素D₃, ≥99% (HPLC)

Sigma-Aldrich

蔗糖, ≥99.5% (GC), BioReagent, suitable for cell culture, suitable for insect cell culture

Sigma-Aldrich

蔗糖, ≥99.5% (GC)

Sigma-Aldrich

蔗糖, ≥99.5% (GC), Grade II, suitable for plant cell culture

Supelco

十二烷基硫酸钠, dust-free pellets, suitable for electrophoresis, for molecular biology, ≥99.0% (GC)

Sigma-Aldrich

十二烷基硫酸钠, ACS reagent, ≥99.0%

Sigma-Aldrich

十二烷基硫酸钠, ≥98.0% (GC)

Sigma-Aldrich

蔗糖, Grade I, ≥99% (GC), suitable for plant cell culture

Supelco

蔗糖, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

十二烷基硫酸钠, ReagentPlus^®, ≥98.5% (GC)

Sigma-Aldrich

蔗糖, meets USP testing specifications

Sigma-Aldrich

十二烷基硫酸钠, tested according to NF, mixture of sodium alkyl sulfates consisting mainly of sodium dodecyl sulfate

Sigma-Aldrich

蔗糖, ACS reagent

Millipore

蔗糖, suitable for microbiology, ACS reagent, ≥99.0%

Sigma-Aldrich

1α,25-二羟基维生素D₃, ≥97.0% (HPLC)

Sigma-Aldrich

蔗糖, puriss., meets analytical specification of Ph. Eur., BP, NF

Sigma-Aldrich

十二烷基硫酸钠, BioXtra, ≥99.0% (GC)

Supelco

1α,25-二羟基维生素D2标准液溶液, 5 μg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant^®

Sigma-Aldrich

十二烷基硫酸钠, 92.5-100.5% based on total alkyl sulfate content basis

Supelco

十二烷基硫酸钠, suitable for ion pair chromatography, LiChropur^™, ≥99.0%