Y0002361

Saxagliptin

for system suitability CRS, European Pharmacopoeia (EP) Reference Standard

• 别名: Saxagliptin hydrate, (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile hydrate, BMS 477118, BMS 477118-11, BMS-477118, BMS-477118-11, BMS477118, BMS477118-11
• 经验公式（希尔记法）: C₁₈H₂₅N₃O₂ · H₂O
• CAS号: 945667-22-1
• 分子量: 333.43
• UNSPSC代码: 41116107
• NACRES: NA.24

属性

• 等级: pharmaceutical primary standard
• API类: saxagliptin
• 制造商/商品名称: EDQM
• 应用: pharmaceutical
• 储存温度: 2-8°C
• SMILES字符串: OC12CC([C@@H](C(N3[C@@H](C[C@]4([C@@]3(C4)[H])[H])C#N)=O)N)(CC(C5)C2)CC5C1.O
• InChI: 1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1
• InChI key: AFNTWHMDBNQQPX-NHKADLRUSA-N

说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Saxagliptin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Orally active, highly potent & long-acting dipeptidyl peptidase IV (DPP-IV) inhibitor with therapeutic efficacy against type II diabetes in vivo.

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

包装

Unit quantity: 1.082mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

安全信息

• 象形图: GHS08
• 警示用语：: Danger
• 危险声明: H317,H334,H361fd,H372
• 预防措施声明: P202 - P260 - P264 - P280 - P302 + P352 - P308 + P313
• 危险分类: Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT RE 1
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable