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58151AST

CHIRALPAK® AGP (5 μm) HPLC Columns

L × I.D. 15 cm × 4 mm, HPLC Column

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1 EA
$7,840.00

$7,840.00


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1 EA
$7,840.00

About This Item

UNSPSC代码:
41115700
eCl@ss:
32110501
NACRES:
SB.52

$7,840.00


请联系客服了解存货情况

产品名称

CHIRALPAK ® AGP HPLC 色谱柱, 5 μm particle size, L × I.D. 15 cm × 4 mm

物料

stainless steel column

Agency

suitable for USP L41

产品线

CHIRALPAK®

包装

pkg of 1 ea

制造商/商品名称

CHIRALPAK®

参数

137 bar pressure (2000 psi)
20-30 °C temperature
40 °C max. temp.

技术

HPLC: suitable

长度 × 内径

15 cm × 4 mm

基质

fully porous particle

基质活性基团

glycoprotein, alpha1- phase

粒径

5 μm

工作pH值

2-8

分离技术

chiral

储存温度

2-8°C

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一般描述

1983 年 Hermansson 描述了如何将天然蛋白质固定在二氧化硅载体上用于手性分离 (1)。蛋白质含有大量一种构型的手性中心,以及许多其他有助于一般保留过程的位点。大赛璐酸性糖蛋白手性柱CHIRALPAK AGP在目前可用的所有蛋白相中具有最广泛的选择性。CHIRALPAK AGP 相使用 α 1 -酸性糖蛋白 (AGP) 作为手性选择剂固定于球形 5μm 二氧化硅颗粒。键合 AGP 是一种非常稳定的蛋白质,可耐受纯有机溶剂、高温和4~7的 pH 值。CHIRALPAK AGP 手性柱在反相模式下运行,可分离极广范围的原料药物(例如酸、胺和中性化合物)的对映体。流动相的 pH 值、离子强度以及有机改性剂的性质和浓度可调节对映选择性和保留值。

特性:

  • 手性分子的直接反相拆分
  • 用多种有机改性剂稳定
  • 提供分析和半制备规格

(1) Hermansson,J. 使用 a1-酸性糖蛋白作为手性固定相直接液相色谱分离外消旋药物。J CHROMATOGR A, 1983, 269, 71-80.

应用


  • Evaluation of R- (-) and S- (+) Clenbuterol enantiomers during a doping cycle or continuous ingestion of contaminated meat using chiral liquid chromatography by LC-TQ-MS: This study demonstrates the use of a chiral HPLC column for the separation of clenbuterol enantiomers in biological samples, providing insights into the detection of doping substances or exposure to contaminated meat (Dolores et al., 2019).

  • Stereochemical characterization of fluorinated 2-(phenanthren-1-yl)propionic acids by enantioselective high performance liquid chromatography analysis and electronic circular dichroism detection: This research highlights the capability of chiral HPLC columns to differentiate between the enantiomers of complex fluorinated compounds, offering a method for detailed analysis crucial in pharmaceutical studies (Bertucci et al., 2012).

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法律信息

CHIRALPAK is a registered trademark of Daicel Corp.

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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