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Merck
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主要文件

577515-U

Supelco

Cyano HPLC 色谱柱 ®

5 μm particle size, L × I.D. 2 cm × 3 mm

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About This Item

UNSPSC代码:
41115700
eCl@ss:
32110501

物料

stainless steel column

Agency

suitable for USP L10

产品线

Discovery®

特点

endcapped

制造商/商品名称

Discovery®

包装

1 ea of

标记范围

4.5% Carbon loading

参数

≤70 °C temp. range
400 bar pressure (5801 psi)

技术

HPLC: suitable
LC/MS: suitable

长度 × 内径

2 cm × 3 mm

表面积

200 m2/g

表面覆盖度

3.5 μmol/m2

杂质

<10 ppm metals

基质

silica gel, high purity, spherical base material
fully porous particle

基质活性基团

cyano phase

粒径

5 μm

孔径

180 Å

工作pH范围

2-8

应用

food and beverages

分离技术

hydrophilic interaction (HILIC)
normal phase
reversed phase

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特点和优势

  • 低疏水性可实现对疏水性化合物的快速洗脱
  • 分析强碱性化合物具有优良的峰形和保留性能
  • 对极性化合物具有较强的保留能力
  • 独特的选择性
  • 保留时间显著小于 C18 柱（通常流动相中所需有机相比例更低）
  • 稳定性好、低流失，适用于 LC-MS 分析
  • 与高含水量的流动相兼容

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法律信息

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
Aaron D Milstein et al.
Trends in pharmacological sciences, 29(7), 333-339 (2008-06-03)
Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by activating AMPA receptors. Depending on its precise size and shape, current through AMPA receptors gates downstream processes like NMDA receptor activation and action potential generation. Over a decade
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
Aleem Gangjee et al.
Journal of medicinal chemistry, 53(22), 8116-8128 (2010-10-27)
Two classes of molecules were designed and synthesized based on a 6-CH(3) cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate and acetamidine, which in turn was chlorinated and reacted with the appropriate anilines to
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
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相关内容

Discovery® HPLC Columns for Fast LC-MS Analysis

Discovery® HPLC Columns for Fast LC-MS Analysis. The Discovery LC-MS line offers short length columns for fast LC-MS analysis that are rugged and dependable. Supelco offers a robust product that withstands column shock due to fast gradient turnaround times.

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