推荐产品
化驗
≥97% (HPLC)
形狀
solid
顏色
white to off-white
溶解度
DMSO: ≥5 mg/mL
起源
Sanofi Aventis
儲存溫度
2-8°C
SMILES 字串
Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2
InChI
1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H
InChI 密鑰
WVHBEIJGAINUBW-UHFFFAOYSA-N
基因資訊
human ... HTR1A(3350)
生化／生理作用
5-HT1A serotonin receptor agonist; neuroprotectant
特點和優勢
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials.
Vincent Meininger et al.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 5(2), 107-117 (2004-06-19)
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal motor neuron disease. We carried out two randomized, double-blind, placebo-controlled, multi-centre, multi-national studies with xaliproden (a drug with neurotrophic effect) to assess drug efficacy and safety at two doses. Patients
Y Iwasaki et al.
Journal of the neurological sciences, 160 Suppl 1, S92-S96 (1998-12-16)
SR57746A(1-[2-(naphth-2-yl)ethy]]-4-(3-trifluoromethyl phenyl)-1,2,5,6-tetrahydropyridine, hydrochloride) is a non-peptide compound which has been shown to exhibit a wide range of neurotrophic effects both in vitro and in vivo. Here we examine the ability of SR57746A on axotomized spinal motor neuron death in the
J-C Martel et al.
British journal of pharmacology, 158(1), 232-242 (2009-06-11)
Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats. Xaliproden was tested on
J P Terranova et al.
Neuroscience letters, 213(2), 79-82 (1996-08-02)
Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 17(2), 157-164 (2004-06-03)
Compounds possessing neurotrophic properties may represent a possible treatment for neurodegenerative disorders such as amyotrophic lateral sclerosis. Xaliproden (SR57746A), an orally-active non-peptide compound, which has been found to exhibit neurotrophic effects in vitro and in vivo, increased the lifespan and
商品
We offer many products related to serotonin receptors for your research needs.
我们提供许多血清素受体相关产品，满足您的各类研究需求。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门