U111
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
solid, ≥98% (HPLC)
别名:
trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
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5 MG
$136.00
25 MG
$445.00
100 MG
$1,360.00
About This Item
经验公式（希尔记法）:
C19H26Cl2N2O · HCl · xH2O
CAS号:
分子量:
405.79 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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方案
≥98% (HPLC)
表单
solid
旋光性
[α]22/D -39.0 to -32.0°, c = 0.5 in methanol(lit.)
储存条件
desiccated
颜色
white
溶解性
H2O: 13 mg/mL
储存温度
2-8°C
SMILES字符串
O.Cl.CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H26Cl2N2O.ClH.H2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H;1H2/t17-,18-;;/m0../s1
InChI key
UWPRPWMHQDPOFR-MPGISEFESA-N
基因信息
human ... OPRK1(4986)
应用
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta)[1].
生化/生理作用
Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.
制备说明
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D D Taub et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(2), 360-364 (1991-01-15)
Opioids and opioid peptides have been shown by numerous laboratories to modulate various parameters of the immune response, but little attention has been given to the type of opioid receptor that might be involved. This study focuses on the in
Stephen M Johnson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 295(5), R1599-R1612 (2008-09-12)
For ectothermic vertebrates, such as reptiles, the effects of opioid receptor subtype activation on breathing are poorly understood. On the basis of previous studies on mammals and lampreys, we hypothesized that mu- and delta-opioid receptor (MOR and DOR, respectively) activation
Stereospecific inhibition of gastro-intestinal transit by κ-opioid agonists in mice.
Ramabadran, et al.
European Journal of Pharmacology, 155, 329-329 (1991)
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