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化驗
≥99%
形狀
powder
顏色
white to off-white
溶解度
DMF: soluble 50 mg/mL
抗生素活性譜
fungi
parasites
作用方式
enzyme | inhibits
SMILES 字串
c1ccc2[nH]c(nc2c1)-c3cscn3
InChI
1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChI 密鑰
WJCNZQLZVWNLKY-UHFFFAOYSA-N
基因資訊
human ... CYP2C9(1559)
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一般說明
化学结构式：咪唑
應用
噻苯唑 (TBZ) 是一种广谱抗蠕虫药，用于治疗人体寄生虫感染。用作农业杀菌剂和食品防腐剂 。噻苯唑已被用作重金属螯合解毒剂。临床上用于治疗线虫病、皮肤幼虫移行症、内脏幼虫移行症及旋毛虫病等 。
生化／生理作用
噻苯唑在线粒体蠕虫特异性酶级别抑制无氧呼吸。在 空肠弯曲菌 和 幽门螺杆菌 中作为一种醌醇富马酸还原酶 (QFR) 抑制剂，阻断醌氧化为醌。噻苯达唑抑制虫卵和幼虫的产生，并可能抑制随粪便排出的虫卵和幼虫的后续发育 。噻苯达唑的一种生物转化途径是 CYP1A2 催化的羟基化反应，生成 5-羟基噻苯达唑，后者被代谢为葡糖苷酸和硫酸盐结合物 。
其他說明
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510)：非易燃固体
訊號詞
Warning
危險聲明
危險分類
Aquatic Acute 1 - Aquatic Chronic 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
其他客户在看
Roslyn S Thelingwani et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(6), 1286-1294 (2009-03-21)
Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence and presence of NADPH. TDI was observed with both compounds, with k(inact) and K(I) values
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Cell reports, 30(8), 2686-2698 (2020-02-27)
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Brazil is one of the world's largest producers of animal protein, requiring the large-scale use of veterinary drugs. The administration of antimicrobials and antiparasitics is a common practice. However, there is a lack of information on how these drugs impact
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The Analyst, 136(21), 4392-4396 (2011-09-06)
We describe a rapid in situ method for detecting agrochemicals on the surface or in the tissue of fruit using a portable mass spectrometer equipped with an ambient ionization source. Two such ionization methods, low temperature plasma (LTP) and paper
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