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品質等級
化驗
≥90% (by assay)
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white to brown
儲存溫度
room temp
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI 密鑰
YPHMISFOHDHNIV-FSZOTQKASA-N
一般說明
一种抗真菌抗生素，可抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。直接与易位酶相互作用，干扰易位步骤。抑制真核生物中无细胞蛋白的合成。 竞争性抑制hFKBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt′s淋巴瘤细胞和包括啮齿动物巨噬细胞在内的多种其他细胞类型中引发凋亡。诱导巨噬细胞中的DNA片段化，但抑制用毒胡萝卜素，甲基泼尼松龙和离子霉素处理的大鼠胸腺细胞中的DNA裂解。在碱性溶液中迅速被破坏。
一种抗真菌抗生素，可抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。竞争性抑制hFKBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt’s淋巴瘤细胞和其他细胞类型中引发凋亡。也可获得100 mg/mL环己酰亚胺（目录编号239765）的DMSO溶液（无菌过滤）。
警告
毒性：高毒性 & 致癌性/致畸性（I）
其他說明
Christner, C., et al. 1999.J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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