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5 MG
$391.00
25 MG
$1,030.00
About This Item
经验公式(希尔记法):
C12H8ClN3O3
CAS号:
分子量:
277.66
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2
InChI
1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChI key
FRPJSHKMZHWJBE-UHFFFAOYSA-N
一般描述
应用
生化/生理作用
T0070907 在结构和活性方面与 PPAR-γ 拮抗剂 GW9662非常相似。T0070907 对 PPAR-γ 作用更强,选择性超过所有其他亚型(约 800 倍),而 GW9662 据报道有一些 PPAR-α激动剂活性。
T0070907 是一种 PPAR-γ拮抗剂。
制备说明
T0070907 可溶于 DMSO,浓度大于 10 mg/mL。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Changsung Kim et al.
Nature, 494(7435), 105-110 (2013-01-29)
Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing
Sreedevi Avasarala et al.
Biology open, 2(7), 675-685 (2013-07-19)
In non-small cell lung cancer cell lines, activation of β-catenin independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differentiation. miRNA expression profiling on a human lung adenocarcinoma cell line (A549)
E M Schuman et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(25), 11958-11962 (1994-12-06)
Recent studies of long-term potentiation (LTP) in the CA1 region of the hippocampus have demonstrated that nitric oxide (NO) may be involved in some forms of LTP and have suggested that postsynaptically generated NO is a candidate to act as
T0070907, a PPAR gamma inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe
An Z, et al.
Reproductive Sciences, 21(11), 1352-1361 (2014)
Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease
Li HD, et al.
International Immunopharmacology, 50, 95-106 (2017)
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