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Merck

T8691

Sigma-Aldrich

牛磺酸

suitable for cell culture, BioXtra, meets USP testing specifications

别名:

2-氨基乙磺酸

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25 G
$111.00
100 G
$295.00
1 KG
$1,360.00

About This Item

线性分子式:
NH2CH2CH2SO3H
CAS号:
分子量:
125.15
Beilstein:
1751215
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

$111.00


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产品名称

牛磺酸, suitable for cell culture, meets USP testing specifications

Agency

meets USP testing specifications

产品线

BioXtra

表单

crystalline powder

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

颜色

white

mp

>300 °C (lit.)

SMILES字符串

NCCS(O)(=O)=O

InChI

1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)

InChI key

XOAAWQZATWQOTB-UHFFFAOYSA-N

基因信息

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应用

牛磺酸已用于以下情形:
  • 作为心肌细胞解离溶液的组分[1]
  • 作为改性合成输卵管液(m-SOF)培养基的补充剂,用于培养假定的受精卵[2]
  • 作为低Ca2+溶液的组成部分,用于制备胶原酶B溶液,将菌落分解成单个细胞[3]
  • 体外受精过程中评估与不同牛精子受精后对牛胚胎发育的影响[4]
  • 作为角膜类器官衍生培养基的组分[5]

生化/生理作用

牛磺酸主要存在于视网膜和心脏,也存在于脑、肠、骨骼肌和肾中。牛磺酸可以调节细胞内钙浓度,防止缺血再灌注损伤并具有降血压特性。牛磺酸还在胆汁形成和脂肪消化中发挥作用。牛磺酸缺乏与焦虑、多动、癫痫和抑郁有关。[6]
甘氨酸受体的非选择性内源激动剂。
甘氨酸受体的非选择性内源激动剂。在某些细胞中调节细胞凋亡的条件必需磺化氨基酸;在许多新陈代谢活动中起作用;是蛋氨酸和半胱氨酸的代谢产物。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Scalable expansion of human pluripotent stem cells in suspension culture
Zweigerdt R, et al.
Nature Protocols, 6(5), 689-689 (2011)
Cornea organoids from human induced pluripotent stem cells
Foster JW, et al.
Scientific Reports, 7 (2017)
The Effect of Various Concentrations of Taurine during In vitro Fertilization on the Development of Bovine Embryos Fertilized with Spermatozoa from Three Different Bulls
Tsuzuki Y, et al.
Asian-Australasian Journal of Animal Sciences (2010)
Patient-specific induced pluripotent stem cell models: generation and characterization of cardiac cells
Zanella F and Sheikh F
Methods in Molecular Biology, 147-162 (2014)
The potential health benefits of taurine in cardiovascular disease.
Xu YJ
Experimental and Clinical Cardiology, 13(2), 57-65 (2008)

商品

Milli-Q® 系统产出的超纯水不含BPA,适合用于胚胎学研究,最大限度地减少内分泌干扰物的干扰。

Ultrapure water from Milli-Q® system shown free of BPA, suitable for embryology research, minimizing endocrine disruptor interference.

Questions

1–3 of 3 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What are the recommendations for suspension and storage?

    1 answer
    1. This product is tested for solubility in water at 25 mg/mL. Other solvents have not been investigated. While this material is expected to be stable in solution, stability studies have not been performed. Other sources suggest that stock solutions are stable in aliquots at -20°C. Please see the link below to review a publication that may be helpful:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128499/

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