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Merck

T7750

Sigma-Aldrich

2-硫脲嘧啶

≥99%

别名:

(2-硫亚基-2, 3-二氢嘧啶-4(1H)-酮), 2TU, 4-羟基-2-巯基嘧啶

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25 G
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25 G
$90.40
100 G
$248.00
250 G
$416.00
1 KG
$1,190.00

About This Item

经验公式(希尔记法):
C4H4N2OS
CAS号:
分子量:
128.15
Beilstein:
112227
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

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生物源

synthetic

品質等級

化驗

≥99%

形狀

powder

mp

>300 °C (lit.)

溶解度

1 M NaOH: 5 mg/mL, clear to very slightly hazy
1 M NaOH: 50 mg/mL, colorless to faintly yellow

SMILES 字串

O=C1NC(=S)NC=C1

InChI

1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI 密鑰

ZEMGGZBWXRYJHK-UHFFFAOYSA-N

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一般說明

2-硫脲嘧啶(2-Thiouracil)是尿嘧啶的硫代衍生物,是一种嘧啶核碱基。[1]这种抗甲状腺药物在H2O &有机溶剂中的溶解度较低。[2]

應用

2-硫脲嘧啶可用于:

  • 银溶胶和膜基底的合成和表征,以及它们在表面增强拉曼光谱(SERS)中的应用。[1]
  • 研究其在二氧化钛(TiO2)纳米粒子改性金电极上的电氧化行为和测定方法[3]
  • 通过时间分辨光电子能谱研究甲基化对2-硫脲嘧啶的失活机制或三重态动力学的影响[4]

生化/生理作用

2-硫尿嘧啶可作为抗癌、抗甲状腺和抗病毒剂。2-硫脲嘧啶是一种选择性黑色素瘤探测物和神经元一氧化氮合酶的竞争性抑制剂。[5]可与金(Au)、铬(Cr)、锌(Zn)和银(Ag)等过渡金属形成络合物。[1]2-硫脲嘧啶可加入组织培养基,在化疗期间抑制病毒复制或从感染组织转移到健康组织。[6]

象形圖

Health hazard

訊號詞

Warning

危險聲明

危險分類

Carc. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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其他客户在看

A Palumbo et al.
FEBS letters, 485(2-3), 109-112 (2000-11-30)
2-thiouracil (TU), an established antithyroid drug and melanoma-seeker, was found to selectively inhibit neuronal nitric oxide synthase (nNOS) in a competitive manner (K(i)=20 microM), being inactive on the other NOS isoforms. The drug apparently interfered with the substrate- and tetrahydrobiopterin
Silver colloid and film substrates in surface-enhanced Raman scattering for 2-thiouracil detection
Al-Shalalfeh MM, et al.
Royal Society of Chemistry Advances, 6, 75282-75292 (2016)
Leslie Gay et al.
Genes & development, 27(1), 98-115 (2013-01-12)
Transcriptional profiling is a powerful approach for understanding development and disease. Current cell type-specific RNA purification methods have limitations, including cell dissociation trauma or inability to identify all RNA species. Here, we describe "mouse thiouracil (TU) tagging," a genetic and
J Vanden Bussche et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(2), 166-172 (2011-01-26)
Thiouracil belongs to the xenobiotic thyreostats, which are growth-promoting agents illegally used in animal production. Recently it has been reported that thiouracil is suspected to have a natural origin. The European Union of Reference Laboratory guidance paper of 2007 acknowledged
Karina Kraszewska et al.
Bioorganic & medicinal chemistry, 19(7), 2443-2449 (2011-03-15)
4-Pyrimidinone ribofuranoside (H(2)o(4)U) and 4-pyrimidinone 2'-deoxyribofuranoside (dH(2)o(4)U) were synthesized by the oxidative desulfurization of parent 2-thiouracil nucleosides with m-chloroperbenzoic acid. The crystal structures of H(2)o(4)U and dH(2)o(4)U and their conformations in solution were determined and compared with corresponding 2-thiouracil and

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