所有图片(1)
About This Item
经验公式（希尔记法）:
C16H14N2O2
CAS号:
分子量:
266.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98%
表单
solid
效能
IC50 (3 micromolar for inhibition of EGF-receptor.)
mp
114-115 °C
溶解性
DMSO or ethanol: soluble
储存温度
2-8°C
SMILES字符串
COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2
InChI
1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
InChI key
DBGZNJVTHYFQJI-UHFFFAOYSA-N
生化/生理作用
Non-phenolic tyrphostin-class tyrosine kinase inhibitor.
制备说明
Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice[1].
Tyrphostin RG 13022 is soluble in DMSO and ethanol.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
T Yoneda et al.
Cancer research, 51(16), 4430-4435 (1991-08-15)
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated with the loss of the normal regulation of the EGF receptor signal transduction pathway.
K B Reddy et al.
Cancer research, 52(13), 3636-3641 (1992-07-01)
Human breast cancer cell proliferation is regulated by growth factors that bind to receptors with intrinsic tyrosine kinase (TK) activity, including the epidermal growth factor (EGF) receptor. To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied
S Oomizu et al.
The Journal of endocrinology, 165(2), 493-501 (2000-05-16)
Oestrogen stimulates the proliferation of pituitary cells. The present study was designed to clarify the involvement of transforming growth factor-alpha (TGF-alpha) in the oestrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR male mice were
S Takahashi et al.
Archives of physiology and biochemistry, 110(1-2), 34-41 (2002-04-06)
Estrogen stimulates the proliferation of pituitary cells, in particular mammotrophs. The present study was designed to clarify involvement of transforming growth factor alpha (TGF-alpha) in the estrogen-induced growth of mouse pituitary cells in vitro. Anterior pituitary cells obtained from ICR
B S Kondapaka et al.
Molecular and cellular endocrinology, 117(1), 53-58 (1996-03-01)
In prostate cancer cells, the binding of peptide growth factors to specific receptors increases tyrosine kinases (TK) activity to regulate cell proliferation, cell differentiation, and signaling processes. To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied
Active Filters
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门
