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生物来源
human
重组
expressed in HEK 293 cells
方案
≥95% (SDS-PAGE)
表单
liquid
分子量
~37 kDa
包装
pkg of 10 μg
pkg of 50 μg
浓度
0.2 μM
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CTSS(1520)
一般描述
生化/生理作用
Cathepsin S (CTSS) is a key participant in MHC (major histocompatibility complex) class II-mediated immune responses, where CTSS degrades Ii (type II membrane glycoprotein invariant chain) sequence of MHC II aβ heterodimers. Ii contains signaling motifs and its degradation leads to successful association of class II associated invariant chain peptide (CLIP) with the peptide groove of the MHC class II molecule. This is essential for antigen loading on MHC II complex during antigen presentation.[1] Overexpression of this protein in mice leads to increased proteinase-activated receptor-2 (PAR-2) expression in dendritic cells resulting in scratching behavior and Th1 (T-helper) cell-associated cytokine expression. This can eventually lead to chronic atopic dermatitis in mice.[2]
外形
A 0.2 μM filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Sarah F Hamm-Alvarez et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1872-1881 (2014-03-20)
The diagnosis of Sjögren's syndrome (SS) in routine practice is largely a clinical one and requires a high index of suspicion by the treating physician. This great dependence on clinical judgment frequently leads to delayed diagnosis or misdiagnosis. Tear protein
Nari Kim et al.
The Journal of investigative dermatology, 132(4), 1169-1176 (2011-12-16)
Atopic dermatitis (AD) is a chronically relapsing, non contagious pruritic skin disease with two phases: acute and chronic. Cysteine protease cathepsin S (CTSS) is involved in inflammatory processes, possibly leading to atherosclerosis and asthma. Recently, it has been reported that
Si-Tu Xue et al.
RSC advances, 9(15), 8600-8607 (2019-03-14)
Cathepsin K (Cat K) is a predominant cysteine protease and highly potent collagenase expressed in osteoclasts. Cat K inhibitors are anti-resorptive agents to treat osteoporosis. A novel scaffold of cathepsin K inhibitors, exemplified by lead compound 1x, was used as
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