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Merck

SRP5355

Sigma-Aldrich

MYT1, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

DKFZp547K1610, FLJ20093, PKMYT1

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.32
价格与库存信息目前不能提供

生物来源

human

重组

expressed in baculovirus infected Sf9 cells

方案

≥70% (SDS-PAGE)

表单

buffered aqueous glycerol solution

分子量

~93 kDa

NCBI登记号

应用

cell analysis

运输

dry ice

储存温度

−70°C

基因信息

human ... PKMYT1(9088)

相关类别

一般描述

The PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) gene is differentially expressed between fetal liver and postnatal liver.[1] This gene is mapped to human chromosome 16p13.3.[2] It is also known to be localized to immature oocytes.[3] MYT1 (myelin transcription factor 1) is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn2+, but not other divalent cations.

生化/生理作用

The PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) gene expression is essential for disease progression of colorectal cancer and hepatocellular carcinoma.[4] The action of Cdc2 (cyclin-dependent kinase 2), an essential molecule required for the induction of mitosis, is regulated by PKMYT1.[3] PKMYT1 binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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访问文档库

PKMYT1 promoted the growth and motility of hepatocellular carcinoma cells by activating beta-catenin/TCF signaling
Liu L, et al.
Experimental Cell Research, 358(2), 209-216 (2017)
Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit
Nakajima H, et al.
The Journal of Cell Biology, 181(1), 89-103 (2008)
Protein kinase, membrane-associated tyrosine/threonine 1 is associated with the progression of colorectal cancer
Jeong D, et al.
Oncology Reports, 39(6), 2829-2836 (2018)
Matthew K Iyer et al.
Nature genetics, 47(3), 199-208 (2015-01-20)
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology and disease processes including cancer. To delineate genome-wide lncRNA expression, we curated 7,256 RNA sequencing (RNA-seq) libraries from tumors, normal tissues and cell lines comprising over 43 Tb

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