SRP5355

MYT1, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 别名: DKFZp547K1610, FLJ20093, PKMYT1
• CAS号: 187414-13-7
• UNSPSC代码: 12352202
• NACRES: NA.32

属性

• 生物来源: human
• 重组: expressed in baculovirus infected Sf9 cells
• 方案: ≥70% (SDS-PAGE)
• 表单: buffered aqueous glycerol solution
• 分子量: ~93 kDa
• NCBI登记号: NM_004203
• 应用: cell analysis
• 运输: dry ice
• 储存温度: −70°C
• 基因信息: human ... PKMYT1(9088)

说明

一般描述

The PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) gene is differentially expressed between fetal liver and postnatal liver.[1] This gene is mapped to human chromosome 16p13.3.[2] It is also known to be localized to immature oocytes.[3] MYT1 (myelin transcription factor 1) is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn2+, but not other divalent cations.

生化/生理作用

The PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) gene expression is essential for disease progression of colorectal cancer and hepatocellular carcinoma.[4] The action of Cdc2 (cyclin-dependent kinase 2), an essential molecule required for the induction of mitosis, is regulated by PKMYT1.[3] PKMYT1 binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable