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生物源
mouse
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
~32.6 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Pgf(18654)
一般說明
PLGF (also called Placenta Growth Factor, PIGF, PGF) is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PLGF is expressed in placental tissues, colon and mammary carcinomas. It signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains.
外觀
Sterile filtered and lyophilized with no additives.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Changjun He et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 47(6), 2534-2543 (2018-07-11)
Assistance with tumor-associated vascularization is needed for the growth and invasion of non-small cell lung cancer (NSCLC). Recently, it was shown that placental growth factor (PLGF) expressed by NSCLC cells had a critical role in promoting the metastasis of NSCLC
Zanfeng Wang et al.
Molecular and cellular biochemistry, 439(1-2), 163-169 (2017-09-02)
Vascular endothelial growth factor (VEGF) family members play critical and complex roles in the regulation of cancer vascularization and metastasis. The exact molecular control of lung cancer metastasis by VEGF family members is not completely understood. Here, we showed that
Huaifeng Li et al.
Cancer science, 109(5), 1532-1544 (2018-03-27)
Gallbladder cancer (GBC) is the most common malignant tumor of the biliary tract system. Epithelial-mesenchymal transition (EMT) plays a vital role in the process of tumor metastasis. Mesenchymal-like cells can serve as a source of cancer stem cells, which can
Xu Zhou et al.
Scientific reports, 5, 10071-10071 (2015-05-12)
Cancer neovascularization plays an essential role in the metastasis of larynx carcinoma (LC). However, the underlying molecular mechanisms are not completely understood. Recently, we reported that placental growth factor (PLGF) regulates expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling
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