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生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
~19.5 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... FGF21(26291)
一般說明
FGF21 (fibroblast growth factor) belongs to FGF superfamily. It is generated by the liver. The gene is mapped to human chromosome 19q13.33.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.
Recombinant Human FGF-21 produced in Escherichia coli is a single, non-glycosylated polypeptide chain containing 182 amino acids and having a molecular mass of 19.5kDa.
生化／生理作用
FGF21 (fibroblast growth factor) is a hormonal factor which controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. It also possesses autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also involved in bone loss. FGF21 exhibits hepatoprotective properties.
外觀
Lyopohilized from 10 mM Tris, pH 7.5 plus 100 mM NaCl.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X
Cell Metabolism, 22, 811-824 (2015)
Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu AY
Human Molecular Genetics, 22, 1895-1902 (2013)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
Coppage AL
PLoS ONE, 11, e0151269-e0151269 (2016)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
Dunshee DR
The Journal of Biological Chemistry, 291, 5986-5996 (2016)
Wen-Pin Huang et al.
Journal of cellular and molecular medicine, 26(8), 2451-2461 (2022-03-22)
Circulating endothelial progenitor cells (EPCs), which function in vascular repair, are the markers of endothelial dysfunction and vascular health. Fibroblast growth factor 21 (FGF21), a liver-secreted protein, plays a crucial role in glucose homeostasis and lipid metabolism. FGF21 has been reported
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