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Merck
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主要文件

SRP4053

Sigma-Aldrich

FGF-8 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

别名:

AIGF, FGF-8b, FGF8, Fibroblast Growth Factor-8, HBGF

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥95% (SDS-PAGE)

形狀

lyophilized

效力

≥2x10^6 units/mg

分子量

~22.4 kDa

包裝

pkg of 25 μg

儲存條件

avoid repeated freeze/thaw cycles

雜質

endotoxin, tested

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... FGF8(2253)

一般說明

Fibroblast growth factor-8 (FGF-8) is also known as androgen-induced growth factor (AIGF). It is a heparin-binding growth factor. The gene encoding this protein is localized on human chromosome 10.[1] Recombinant human FGF-8 is a 22.4kDa protein containing 193 amino acid residues.

生化/生理作用

Fibroblast growth factor-8 (FGF-8) stimulates the proliferation and activation of cells that express the FGF receptors. It has a role in embryogenesis. FGF8b, an isoform of FGF-8, is expressed in prostate cancer.[2][1]

外觀

Lyophilized in 10 mM Tris, pH 8.0 plus 75 mM NaCl. The protein may appear as a haze or film, which may not be seen at the bottom of the vial.

重構

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1 mg/mL. This solution can be diluted into other aqueous buffers.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Karolina Jendryczko et al.
Frontiers in pharmacology, 12, 748936-748936 (2021-12-07)
Targeted therapies are a promising alternative to conventional chemotherapy, with an increasing number of therapeutics targeting specific molecular aberrancies in cancer cells. One of the emerging targets for directed cancer treatments is fibroblast growth factor receptors (FGFRs), which are known
Screening a phage display library for a novel FGF8b-binding peptide with anti-tumor effect on prostate cancer.
Wang W
Experimental Cell Research, 319(8), 1156-1164 (2013)
A novel locus of ectodermal dysplasia maps to chromosome 10q24.32-q25.1.
Rafiq MA
The Journal of Investigative Dermatology, 124(2), 338-342 (2005)

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