SRP3111
MDC (67 aa) (CCL22) human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
别名:
ABCD-1, CCL22, Macrophage-Derived Chemokine, STCP-1
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20 μG
$510.00
$510.00
预计发货时间2025年5月30日详情
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20 μG
$510.00
About This Item
UNSPSC代码:
12352202
NACRES:
NA.32
$510.00
预计发货时间2025年5月30日详情
新价格，新优惠！
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生物来源
human
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
分子量
8.0 kDa
包装
pkg of 20 μg
技术
cell culture | mammalian: suitable
杂质
<0.1 EU/μg endotoxin, tested
颜色
white to off-white
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CCL22(6367)
一般描述
Macrophage-derived chemokine (MDC) is also known as C-C motif chemokine ligand 22 (CCL22). It is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated natural killer (NK) cells and cluster of differentiation 4 (CD4) T cells. The gene encoding it is localized on human chromosome 16.[1] Recombinant human MDC is an 8.0kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.[2]
生化/生理作用
Macrophage-derived chemokine (MDC) signals through the C-C chemokine receptor type 4 (CCR4). It chemo-attracts monocytes, dendritic cells and natural killer (NK) cells and aids in their function.[1][2] The protein exerts human immunodeficiency virus (HIV) suppressive activity.[3] The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. It is expressed in various cancers and is involved in recruitment of regulatory T cells (Treg) within a tumor.[4]
序列
YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ
外形
Lyophilized with no additives.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ting Fan Leung et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 14(4), 296-301 (2003-08-13)
Chemokines are responsible for the trafficking of leukocytes to sites of inflammation. Serum chemokine levels were previously shown to be increased in adult patients with atopic dermatitis (AD). We tested whether serum concentrations of chemokines, including macrophage-derived chemokine (MDC), thymus
S Struyf et al.
Journal of immunology (Baltimore, Md. : 1950), 161(6), 2672-2675 (1998-09-22)
Posttranslational processing of chemokines increases (IL-8) or decreases (monocyte chemotactic protein-1) their chemotactic potency. Macrophage-derived chemokine (MDC) attracts monocytes, dendritic cells, activated lymphocytes, and NK cells and has reportedly anti-HIV-1 activity. Here we report that truncation of MDC by deletion
Soluble factors from T cells inhibiting X4 strains of HIV are a mixture of ? chemokines and RNases.
Cocchi F
Proceedings of the National Academy of Sciences of the USA, 109(14), 5411-5416 (2012)
Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.
Godiska R
The Journal of Experimental Medicine, 185(9), 1595-1604 (1997)
Genetic Polymorphisms of CCL22 and CCR4 in Patients with Lung Cancer.
Erfani N
Iranian Journal of Medical Sciences, 39(4), 367-373 (2014)
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