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Merck

SRP3015

Sigma-Aldrich

β NGF 人

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

别名:

β-神经生长因子

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥98% (HPLC)
≥98% (SDS-PAGE)

形狀

lyophilized

效力

<1.0 ng/mL ED50

分子量

13.5 kDa

包裝

pkg of 20 μg

技術

cell culture | mammalian: suitable

雜質

<0.1 EU/μg endotoxin, tested

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... NGF(4803)

一般說明

β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。这些蛋白质属于生长因子的半胱氨酸结家族,其具有稳定的二聚体结构。β-NGF 是一种强神经营养因子,通过其受体 β-NGFR 传递信号,在感觉和交感神经系统的发育和保存中起着至关重要的作用。β-NGF 还作为 B 淋巴细胞的生长和分化因子,并促进 B 细胞的存活。人 β-NGF 的功能形式是非共价二硫键连接的同源二聚体,具有两个 13.5kDa 多肽单体(总共 240 个氨基酸残基)。这三个二硫键是生物活性所必需的。

應用

人β NGF 已被用于免疫组织化学。

生化/生理作用

β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。人 b-NGF 的功能形式是非共价二硫键连接的同源二聚体,具有两个 13.5kDa 多肽单体(总共 240 个氨基酸残基)。这三个二硫键是生物活性所必需的。

序列

SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

外觀

冻干品,无添加剂。

重構

在打开之前离心小瓶。在水中重悬至浓度为 0.1-1.0 mg/ml。不要涡旋。该溶液可在 2-8℃ 下储存长达 1 周。要于长期储存,建议在含有载体蛋白(例如 0.1% BSA)的缓冲液中进一步稀释,并以 工作等分试样储存于 -20°C 至 -80°C。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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H Zhang et al.
European journal of histochemistry : EJH, 59(3), 2522-2522 (2015-10-03)
The nerve growth factor (NGF) not only has an essential effect on the nervous system, but also plays an important role in a variety of non-neuronal systems, such as the reproductive system. The aim of this study was to investigate
The nerve growth factor 35 years later.
R Levi-Montalcini
Science (New York, N.Y.), 237(4819), 1154-1162 (1987-09-04)
Huiyu Chen et al.
Journal of inflammation (London, England), 16, 27-27 (2020-01-01)
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pluripotent neurotrophic factor with immune regulatory effect, was proved to be effective
A Ullrich et al.
Nature, 303(5920), 821-825 (1983-06-30)
Nerve growth factor (NGF) is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurones (see refs 1-3 for review). NGF activity isolated from the male mouse submaxillary gland (MSG) consists of three
Li Xiao et al.
Neural regeneration research, 15(12), 2270-2272 (2020-07-01)
As an aging-associated degenerative disease, Alzheimer's disease is characterized by the deposition of amyloid beta (Aβ), oxidative stress, inflammation, dysfunction and loss of cholinergic neurons. Colla Corii Asini (CCA) is a traditional Chinese medicine which has been used for feebleness-related

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