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生物来源
human
重组
expressed in E. coli
方案
≥80% (SDS-PAGE)
表单
aqueous solution
效能
≥8 nM
分子量
85.5 kDa
包装
pkg of 200 μg
储存条件
avoid repeated freeze/thaw cycles
浓度
>0.02 mg/mL
NCBI登记号
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... HSP90AA2(3324)
一般描述
HSP90α基因定位于人染色体11p14.1。[1]
应用
可用于研究酶动力学、抑制剂筛选和选择性分析。
生化/生理作用
外形
在 25 mM Tris-HCl，pH 7.5，400 mM NaCl，0.05％ Tween 20、10％ 甘油和 3 mM DTT 中配制。
制备说明
在冰上解冻。第一次融化后，短暂旋转含有酶的试管以恢复试管的全部内容物。将酶分装成一次性使用的等分试样。将剩余的未稀释酶等分保存在 -70°C 下。注意：该酶对冻融循环非常敏感。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Bo Qiao et al.
BMC proceedings, 3 Suppl 7, S132-S132 (2009-12-19)
The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.
Eustace BK, et al.
Nature Cell Biology, 6(6), 507-514 (2004)
Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.
McCready J, et al.
BMC Cancer, 10:294 (2010)
Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.
Kunisawa J and Shastri N.
Immunity, 24(5), 523-534 (2006)
Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing.
Cheng CF, et al.
Molecular and Cellular Biology, 28(10), 3344-3358 (2008)
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