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Merck
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主要文件

SRP0134

Sigma-Aldrich

EZH2/EED/SUZ12/RbAp48/AEBP2 human

recombinant, expressed in baculovirus infected insect cells

别名:

ENX-1, EZH2, Enhancer of zeste homolog 2, KMT6A, Lysine N-methyltransferase 6A

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About This Item

UNSPSC代码:
12352200
NACRES:
NA.32

生物来源

human

重组

expressed in baculovirus infected insect cells

方案

≥80% (SDS-PAGE)

表单

aqueous solution

分子量

48 kDa (RbAp48)
51 kDa (EED)
53 kDa (AEBP2)
86 kDa (EZH2)
87 kDa (SUZ12)

包装

pkg of 50 μg

浓度

>0.02 mg/mL

UniProt登记号

运输

dry ice

储存温度

−70°C

基因信息

human ... EZH2(2146)

一般描述

EZH2, EED, SUZ12, RbAp48 and AEBP2 are components of the polycomb repressive complex 2 (PRC2). The highly conserved complex methylates lysine 27 of histone H3. It also has a role in gene silencing and transcription repression.[1][2]

应用

EZH2/EED/SUZ12/RbAp48/AEBP2 human is useful for the study of enzyme kinetics,[3] screening inhibitors and selectivity profiling.

单位定义

One unit is defined as the amount of enzyme required to methylate 1 pmol of substrate/min at 37°C.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Molecular architecture of human polycomb repressive complex 2
Claudio Ciferre
eLife, 1, e00005-e00005 (2012)
The Polycomb Complex PRC2 and its Mark in Life
Raphael Margueron
Nature, 469(7330), 343-349 (2011)
Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the
EZH2-EED Interaction of Polycomb Repressive Complex 2
Xiangqian Kong
Journal of Medicinal Chemistry (2014)
Decoding protein methylation function with thermal stability analysis.
Sayago, et al.
Nature Communications, 14, 3016-3016 (2023)

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