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Merck

SML3727

Sigma-Aldrich

WIC1

≥98% (HPLC)

别名:

N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Wnt Inhibitor Compound 1

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About This Item

经验公式(希尔记法):
C22H23N3O3
分子量:
377.44
UNSPSC代码:
12352200
NACRES:
NA.77
价格与库存信息目前不能提供

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

yellow to brown

溶解性

DMSO:methanol (1:1): 2 mg/mL, clear (Warmed)

储存温度

-10 to -25°C

SMILES字符串

O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2

InChI key

YQXKWSNLAVFZJL-UHFFFAOYSA-N

生化/生理作用

Potent Wnt/β-catenin signaling inhibitor that reduces airway basal stem cell (ABSC) proliferation and induces ciliated cell differentiation.
WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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Cody J Aros et al.
Cell reports, 30(7), 2055-2064 (2020-02-23)
Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression. This led us to develop a model of airway basal

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