SML2590

AZD3463

≥98% (HPLC)

• 别名: AZD 3463, AZD-3463, N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine, N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
• 经验公式（希尔记法）: C₂₄H₂₅ClN₆O
• CAS号: 1356962-20-3
• 分子量: 448.95
• MDL编号: MFCD25976759
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 储存温度: −20°C
• SMILES字符串: ClC1=CN=C(N=C1C2=CNC3=C2C=CC=C3)NC4=CC=C(C=C4OC)N5CCC(CC5)N
• InChI: 1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30)
• InChI key: GCYIGMXOIWJGBU-UHFFFAOYSA-N

说明

生化/生理作用

AZD3463 is an orally available, potent receptor tyrosine kinase (RTK) inhibtor against anaplastic lymphoma kinase ALK (Ki = 0.75 nM; IC50 = 15-21 nM with 5FAM-Srctide as substrate & 30 μM ATP), insulin-like growth factor (IGF)-1 receptor (IGF1R), ROS1 (c-Ros), and Trk-A (NTRK1). AZD3463 effectively inhibits multiple crizotinib-resistant cancer growth and displays in vivo efficacy against FLT3-ITD-dependent MOLM-13 acute myeloid leukemia (AML) as well as NGP (wt ALK) & SH-SY5Y (ALK-F1174L) neuroblastoma in mice (15 mg/kg ip.).

Orally available, potent RTK inhibtor against anaplastic lymphoma kinase (ALK), IGF1R, ROS1 and Trk-A (NTRK1) with in vitro and in vivo anticancer efficacy.

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable