推荐产品
化驗
≥95% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
−20°C
InChI
1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1
InChI 密鑰
FYMHQCNFKNMJAV-HOTGVXAUSA-N
生化／生理作用
Finafloxacin is a fluoroquinolone antibiotic approved by the FDA in 2014 for treating swimmer′s ear. Its mechanism of action involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV
訊號詞
Danger
危險聲明
危險分類
Muta. 1B - Repr. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance.
Linnell B Randall et al.
The Journal of antimicrobial chemotherapy, 72(4), 1258-1260 (2017-01-01)
Jung Won Lee et al.
Antimicrobial agents and chemotherapy, 59(12), 7629-7636 (2015-09-30)
Finafloxacin is a novel fluoroquinolone with improved antimicrobial efficacy, especially in an acidic environment. The efficacy of finafloxacin for the inhibition of Helicobacter pylori infection was compared with the efficacies of levofloxacin and moxifloxacin at neutral and acidic pH. The
Will Stubbings et al.
Antimicrobial agents and chemotherapy, 55(9), 4394-4397 (2011-06-29)
Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were
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