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Merck

SML1954

Sigma-Aldrich

X-34

≥90% (HPLC), powder, amyloid-specific fluorescent dye

别名:

1,4-双(3-羧基-4-羟基苯基乙烯基)苯

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5 MG
$179.00
25 MG
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预计发货时间2025年3月17日详情


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5 MG
$179.00
25 MG
$375.00

About This Item

经验公式(希尔记法):
C24H18O6
分子量:
402.40
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

$179.00


预计发货时间2025年3月17日详情


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产品名称

X-34, ≥90% (HPLC)

品質等級

化驗

≥90% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2.0 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2

InChI

1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)

InChI 密鑰

MCBNOAYTZBUCSX-UHFFFAOYSA-N

生化/生理作用

X-34是一种荧光淀粉样特异性染料。 它与Pittsburgh CompoundB的结合位点不同,并且是β-折叠结构的一种高度荧光标记。
X-34(1,4-双(3-羧基-4-羟基苯基乙烯基)-苯)是参与到降低Aβ42水平(淀粉样-β肽的42个残基异构体)的一种小分子γ-分泌酶调节因子(GSM)。[1]X-34还被用于在活的转基因秀丽隐杆线虫体内对具有经典淀粉样纤维超微结构的细胞内免疫反应性沉积物进行可视化。[2]它还可作为组织化学染色剂用于确定阿尔茨海默氏′病(AD)的病理变化。[3]
荧光淀粉样特异性染料

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
Link CD
Neurobiology of Aging, 22, 217-226 (2001)
S D Styren et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 48(9), 1223-1232 (2000-08-19)
X-34, a lipophilic, highly fluorescent derivative of Congo red, was examined as a histochemical stain for pathological changes in Alzheimer's disease (AD). X-34 intensely stained neuritic and diffuse plaques, neurofibrillary tangles (NFTs), neuropil threads, and cerebrovascular amyloid. Comparison to standard
Taweesak Tangrodchanapong et al.
Molecules (Basel, Switzerland), 26(8) (2021-05-01)
The pathological finding of amyloid-β (Aβ) aggregates is thought to be a leading cause of untreated Alzheimer's disease (AD). In this study, we isolated 2-butoxytetrahydrofuran (2-BTHF), a small cyclic ether, from Holothuria scabra and demonstrated its therapeutic potential against AD
Andy P Tsai et al.
Neurobiology of disease, 153, 105303-105303 (2021-02-26)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1
Substrate-targeting ?-secretase modulators
Kukar TL
Nature, 453, 925-929 (2008)

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