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Merck
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文件

SML1652

Sigma-Aldrich

RGFP966

≥98% (HPLC)

别名:

(2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide, (E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide, RGFP 966

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About This Item

经验公式（希尔记法）:
C21H19FN4O
CAS号:
1396841-57-8
分子量:
362.40
MDL號碼:
MFCD26960954
分類程式碼代碼:
12352200
PubChem物質ID:
329825992
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

NC1=CC(F)=CC=C1NC(/C=C/C(C=N2)=CN2C/C=C/C3=CC=CC=C3)=O

InChI

1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+

InChI 密鑰

BLVQHYHDYFTPDV-VCABWLAWSA-N

生化／生理作用

RGFP966 changes signal-specific primary auditory cortical plasticity. It is highly effective in cardiomyopathy-associated pathologies.
RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 μM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

分析证书(COA)

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Sigma-Aldrich

A3656

5-氮杂-2′-脱氧胞苷

曲古抑菌素A ≥98% (HPLC), from Streptomyces sp.

Sigma-Aldrich

T8552

曲古抑菌素A

槲皮素 ≥95% (HPLC), solid

Sigma-Aldrich

Q4951

槲皮素

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BMC neuroscience, 20(1), 65-65 (2019-12-31)
Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known. HDAC3 is known to be a transcriptional co-repressor. The goal of this study was
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Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo.
Bieszczad KM, et al.
The Journal of Neuroscience, 35(38), 13124-13132 (2015)
Simon J Hogg et al.
Molecular cell, 81(10), 2183-2200 (2021-05-22)
To separate causal effects of histone acetylation on chromatin accessibility and transcriptional output, we used integrated epigenomic and transcriptomic analyses following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological malignancies. We found that catalytic P300/CBP inhibition
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eLife, 9 (2020-05-08)
The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these parasitic loci. Spen
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