Unfortunately, a GMP version of this item is not currently offered. This is the only Cyclosporin H product available at this time.
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生物来源
Tolypocladium inflatum
质量水平
方案
≥97% (HPLC)
表单
powder
旋光性
[α]/D -100 to -115°, c = 0.5 in methanol
储存条件
desiccated
protect from light
颜色
white to beige
储存温度
−20°C
SMILES字符串
N1([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N(C(C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C1=O)CC(C)C)C)C)CC)[C@H](O)[C@@H](C\C=C\C)C)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C
InChI
1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47+,48+,50-,51+,52?,53-/m1/s1
InChI key
BQQHPBPTWWXRMU-SXHXJWHLSA-N
应用
生化/生理作用
环孢菌素 H 是中性粒细胞中甲酰肽受体 1（FPR-1）和甲酰肽诱导的超氧化物形成的选择性抑制剂。
环孢菌素 H 是中性粒细胞中甲酰肽受体 1（FPR-1）和甲酰肽诱导的超氧化物形成的选择性抑制剂。 环孢菌素 H 不结合亲环蛋白或引起免疫抑制反应。 据报道，环孢菌素 H 抑制小鼠皮肤细胞中促进肿瘤的佛波酯 TPA/PMA，并抑制钙/钙调蛋白依赖性的 EF-2 磷酸化。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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シクロスポリンHのGMPグレードはありますか？
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È possibile avere il datasheet del prodotto?
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This product is not tested for use in any specific application and does not include a protocol. It may be helpful to review the Peer Reviewed Papers section of the product page.
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