This product is soluble in water, as well as aqueous buffers. Solutions are stable for up to three months in working aliquots at -20°C. Avoid repeated freeze/thaw cycles. A product datasheet is not available at this time.
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描述
contains 0.5μmol of powder (approx. 0.335mg)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
儲存溫度
−20°C
SMILES 字串
O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H](O)[C@H]3COP5(O)=O
InChI
1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
InChI 密鑰
XRILCFTWUCUKJR-INFSMZHSSA-N
應用
2′,3′-cGAMP钠盐被用来鉴定能够和人干扰素基因（STING）激活剂结合的小分子。它还被用来研究I型干扰素胞浆DNA应答。[1]
生化／生理作用
2′,3′-cGAMP (环化[G(2′,5′)pA(3′,5′)p]) 是STING（干扰素基因激活剂）途径的天然兴奋剂，被发现是抗病毒先天免疫途径。2′3′-cGAMP是在哺乳动物细胞中，由胞质DNA传感器（CGAMP合成酶）通过结合STING，启动干扰素应答，激活先天免疫途径，而产生的二级信使。 2′3′-cGAMP和人STING亲和性比和细菌 3′3′-环化二核苷酸（CDNs）要高得多，1Kd是4.59 nMSTING，相比之下，结合细菌3′3′-CDNs是>1 μM。
2′,3′-cGAMP是hSTING的天然兴奋剂；二级信使环化二核苷酸。
準備報告
2′,3′-cGAMP可溶于水和水性缓冲液（>> 5 mM, 没有确定溶解极限）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Qingyuan Zhu et al.
Antiviral research, 187, 105015-105015 (2021-01-15)
The newly emerged severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) coronavirus initiated a pneumonia outbreak (COVID-19) that rapidly spread worldwide and quickly became a public health emergency of international concern; However to date, except Remdesivir, there are no clinically approved specific or
Christos Dogrammatzis et al.
mBio, 15(4), e0037324-e0037324 (2024-03-12)
The STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses. To counteract STING, HSV-1 has evolved numerous strategies including mechanisms to interfere with its
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The FEBS journal, 291(15), 3432-3453 (2024-04-28)
Inflammatory signals from immunological cells may cause damage to intestinal epithelial cells (IECs), resulting in intestinal inflammation and tissue impairment. Interferon-γ-inducible protein 16 (IFI16) was reported to be involved in the pathogenesis of Behçet's syndrome (BS). This study aimed to
Alice E Denton et al.
The Journal of experimental medicine, 216(3), 621-637 (2019-02-07)
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection-induced pulmonary ectopic germinal centers give rise
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JCI insight, 7(23) (2022-10-28)
Pancreatic neuroendocrine tumors (PNETs) are malignancies arising from the islets of Langerhans. Therapeutic options are limited for the over 50% of patients who present with metastatic disease. We aimed to identify mechanisms to remodel the PNET tumor microenvironment (TME) to
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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