跳转至内容
Merck
所有图片(1)

主要文件

SML1224

Sigma-Aldrich

Torin2

≥98% (HPLC)

别名:

9-(6-氨基-3-吡啶基)-1- [3-(三氟甲基)苯基]-苯并[h] -1,6-萘啶-2(1H)-酮

登录查看公司和协议定价

选择尺寸

5 MG
$212.00
25 MG
$840.00

$212.00


请联系客服了解存货情况

获取大包装报价

选择尺寸

变更视图
5 MG
$212.00
25 MG
$840.00

About This Item

经验公式(希尔记法):
C24H15F3N4O
分子量:
432.40
UNSPSC代码:
12352200
NACRES:
NA.77

$212.00


请联系客服了解存货情况

获取大包装报价

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES字符串

FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChI key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

应用

Torin2已被用于:
  • 检查其对BORCS5-KO细胞中LC3B-II水平的影响[1]
  • 确定其对A2780-顺式卵巢癌细胞的有效活性(IC50小于1 μM)[2]
  • 蛋白质印迹分析[3]

生化/生理作用

Torin2是一种高效且具有选择性的ATP竞争性mTOR抑制剂。
Torin2是一种高效且具有选择性的ATP竞争性mTOR抑制剂。Torin2的IC50为0.25 nM,与PI3K相比,它对mTOR的选择性高800倍。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 1

1 of 1

Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
Sima N, et al.
Translational Oncology, 11(4), 1053-1064 (2018)
BORC coordinates encounter and fusion of lysosomes with autophagosomes
Jia R, et al.
Autophagy, 13(10), 1648-1663 (2017)
AMPK promotes induction of a tumor suppressor FLCN through activation of TFEB independently of mTOR
Collodet C, et al.
bioRxiv, 499921-499921 (2018)
Peter J Mullen et al.
Nature communications, 12(1), 1876-1876 (2021-03-27)
Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. Here we profile metabolic changes conferred by SARS-CoV-2 infection in kidney epithelial cells
Dan Song et al.
Environmental toxicology, 37(7), 1551-1562 (2022-03-04)
The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)-induced apoptosis and oxidative damage in FLK-BLV cells. The results showed that BPA reduced cell viability in a dose- and time-dependent

Questions

Reviews

No rating value

Active Filters

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门