SML0968

Y11

≥98% (HPLC)

• 别名: 1-(2-Hydroxyethyl)-3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide, NSC206142
• 经验公式（希尔记法）: C₈H₁₇N₄O · Br
• CAS号: 1086639-59-9
• 分子量: 265.15
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: H₂O: 25 mg/mL, clear
• 储存温度: −20°C

说明

生化/生理作用

Y11 inhibits the activity of focal adhesion kinase (FAK) by binding to the amino-terminal domain of FAK and blocking autophosphorylation of tyrosine residue Y397. Y11 inhibits the viability of SW620 and BT474 cancer cell lines and significantly reduces tumor volume in mouse xenografts.

Y11 inhibits the activity of focal adhesion kinase (FAK).

Y11 has high cytotoxic effects with IC₅₀ values ranging from 3.87 to 4.66 mM, against non-small cell lung carcinoma (NSCLC) A549 cells.[1] It plays a major role in the protein structures across the kunitz protein domain of viperids and elapids.[2]

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 13 - Non Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable