SML0800

利莫那班 盐酸盐

≥98% (HPLC), powder, cannabinoid type-I receptor antagonist

• 别名: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide hydrochloride, SR-141716, SR-141716A, SR141716, SR141716A
• 经验公式（希尔记法）: C₂₂H₂₁Cl₃N₄O · HCl
• CAS号: 158681-13-1
• 分子量: 500.25
• UNSPSC代码: 12352200
• PubChem化学物质编号: 329825601
• NACRES: NA.77

属性

• 产品名称: 利莫那班 盐酸盐, ≥98% (HPLC)
• 方案: ≥98% (HPLC)
• 表单: powder
• 储存条件: desiccated
• 颜色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 储存温度: 2-8°C
• SMILES字符串: CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NN4CCCCC4)=O.Cl
• InChI: 1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H
• InChI key: REOYOKXLUFHOBV-UHFFFAOYSA-N
• 基因信息: human ... CNR1(1268)

说明

应用

Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:

• to study its effects on protein synthesis in C2C12 myotubes
• to analyze its effects on human astroglia
• in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

生化/生理作用

Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.

Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.

Rimonabant hydrochloride (SR-141716A) is a potent and selecvtive CB1 cannabinoid inverse agonist/antagonist with some GPR55 agonist activity and an appetite suppressant.

特点和优势

This compound is featured on the Cannabinoid Receptors and Cannabinoid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H301,H319
• 预防措施声明: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• 危险分类: Acute Tox. 3 Oral - Eye Irrit. 2
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable