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Merck
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文件

SML0627

Sigma-Aldrich

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

别名:

1- [（1,3-二氢-1,3-二氧代-2H-异吲哚-2-基）乙酰基]-1,2,3,4-四氢-2,2,4-三甲基-喹啉, 2-（2-氧代-2-（2,2,4-三甲基-3,4-二氢喹啉-1 (2H)-基）乙基）异吲哚-1,3-二酮, Mucolipin 合成激动剂 1

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About This Item

经验公式（希尔记法）:
C22H22N2O3
CAS号:
332382-54-4
分子量:
362.42
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

ML-SA1, ≥95% (HPLC)

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

2-8°C

InChI

1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3

InChI 密鑰

KDDHBJICVBONAX-UHFFFAOYSA-N

應用

ML-SA1 已被用作瞬时受体电位阳离子通道粘脂肽 1 (TRPML1/ML1) 激动剂。

生化／生理作用

ML-SA1 是溶酶体粘脂素瞬时受体电位通道 (TRPML) 1、2、3 的一种强效选择性细胞渗透性激动剂，可显著增加 HEK293 细胞稳定或短暂表达突变型 TRPML1 通道 ML1-4A 中的 [Ca 2+] cyt。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
Sahoo N, et al.
Developmental Cell, 41(3), 262-273 (2017)
Hongyan Yu et al.
British journal of cancer, 125(10), 1420-1431 (2021-09-23)
Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca2+ -permeable channels in Pca progression. The
Dengqin Zhong et al.
Nature communications, 14(1), 3997-3997 (2023-07-07)
Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin
Dale P Corkery et al.
EMBO reports, 24(9), e56841-e56841 (2023-06-29)
Lysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms to maintain lysosomal integrity. Small membrane lesions are detected and repaired by the endosomal sorting complex required for transport (ESCRT) machinery while more extensively
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Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The
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