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Merck
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主要文件

SML0619

Sigma-Aldrich

KG-548

≥97% (HPLC)

别名:

5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole

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About This Item

经验公式(希尔记法):
C9H4F6N4
分子量:
282.15
UNSPSC代码:
12352200
NACRES:
NA.77

方案

≥97% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

InChI

1S/C9H4F6N4/c10-8(11,12)5-1-4(7-16-18-19-17-7)2-6(3-5)9(13,14)15/h1-3H,(H,16,17,18,19)

InChI key

KKJFZIQEWZVVIV-UHFFFAOYSA-N

生化/生理作用

KG-548 is an inhibitor of the hypoxia signaling transcription factor complex.
KG-548 is an inhibitor of the hypoxia signaling transcription factor complex. Hypoxia inducible factor (HIF) is a heterodimer of two bHLH-PAS (basic Helix Loop Helix - Per-ARNT-Sim) subunits, including a HIF-α paralog (HIF-1α, -2α, -3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β. KG-548 selectively binds within the ARNT PAS domain of the ARNT subunit of the HIF activator that recruits TACC3 (Transforming Acidic Coiled Coil Containing Protein 3) coactivator, competing with TACC3 for binding to the ARNT PAS-B domain and thus acting as as an ARNT/TACC3 disruptor.

象形图

Skull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3


历史批次信息供参考:

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